Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi Academic Article uri icon

Overview

MeSH Major

  • Contrast Media
  • Factor XIIIa
  • Fibrin
  • Fluorescent Dyes
  • Peptide Fragments
  • Spectroscopy, Near-Infrared
  • Thrombosis
  • alpha-2-Antiplasmin

abstract

  • A15 is a novel optical imaging agent that is specifically crosslinked to fibrin by FXIIIa, permitting detection of FXIIIa activity in experimental thrombi in vivo. This agent should permit assessment of FXIIIa activity in a broad range of biological processes and could aid in the clinical diagnosis of acute thrombi.

publication date

  • July 13, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000134484.11052.44

PubMed ID

  • 15210587

Additional Document Info

start page

  • 170

end page

  • 6

volume

  • 110

number

  • 2