Management of difficult polymyalgia rheumatica and giant cell arteritis: Updates for clinical practice. Review uri icon

Overview

abstract

  • Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) represent a family of systemic inflammatory diseases occurring in adults aged 50 years and above. Clinical presentation of PMR/GCA can be variable, making diagnosis at times challenging. There has been an increased appreciation of the role of various large-vessel imaging modalities to help confirm a diagnosis of GCA. Systemic corticosteroids (CS) remain the mainstay of treatment for both PMR and GCA, yet both relapses and CS-related side effects are common. Recent research has demonstrated efficacy of certain biologic agents in these diseases, with particular emphasis on the role of interleukin-6 (IL-6) blockade in GCA. This chapter discusses the latest updates on the diagnosis and treatment of PMR/GCA, with an emphasis on clinical care.

publication date

  • May 23, 2019

Research

keywords

  • Adrenal Cortex Hormones
  • Giant Cell Arteritis
  • Polymyalgia Rheumatica

Identity

Scopus Document Identifier

  • 85065917131

Digital Object Identifier (DOI)

  • 10.1016/j.berh.2019.04.006

PubMed ID

  • 31427056

Additional Document Info

volume

  • 32

issue

  • 6