Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy Academic Article uri icon

Overview

MeSH Major

  • Cardiomyopathy, Dilated
  • Muscle Proteins
  • Myocardium
  • Protein Kinases

abstract

  • Total titin content was unchanged in end-stage failing hearts and the more compliant N2BA isoform comprised a greater percentage of titin in these hearts. Changes in titin isoform expression in heart failure patients with dilated cardiomyopathy significantly impact diastolic filling by lowering myocardial stiffness. Upregulation of titin-binding proteins indicates that the importance of altered titin expression might extend to cell signaling and regulation of gene expression.

publication date

  • July 13, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000135591.37759.AF

PubMed ID

  • 15238456

Additional Document Info

start page

  • 155

end page

  • 62

volume

  • 110

number

  • 2