Major infections after bypass surgery and stenting for multivessel coronary disease in the randomised SYNTAX trial. Academic Article uri icon

Overview

abstract

  • AIMS: Incidence, associated risk factors and impact on mortality of infections after bypass surgery (CABG) and stenting (PCI) for multivessel coronary disease (MVD) have never been reported in a large randomised trial. The aim of the present study was to evaluate, in patients with MVD, the prevalence of major infections after PCI and CABG and to assess their impact on mortality. METHODS AND RESULTS: The SYNTAX trial randomised 1,800 MVD patients to either CABG or PCI. Patients were followed up to five years. The primary endpoint of this post hoc analysis was the occurrence of major infection. At five years of follow-up, the primary endpoint had occurred in 142 (15.8%) patients in the CABG arm and 44 (4.9%) patients in the PCI arm (≤60 days HR - 7.9, 95% CI: 4.7 to 13.1; p<0.001) (>60 days - HR 0.79, 95% CI: 0.44 to 1.44; p=0.45). Major infections were independently associated with a higher risk of all-cause mortality at five years (adjusted HR 2.6, 95% CI: 1.8 to 3.8, p<0.001). CONCLUSIONS: CABG is associated with a higher incidence of post-procedure major infections compared to PCI. Major infections are independently associated with all-cause mortality.

publication date

  • April 17, 2020

Research

keywords

  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Percutaneous Coronary Intervention
  • Postoperative Complications
  • Surgical Wound Infection

Identity

Scopus Document Identifier

  • 85083371709

Digital Object Identifier (DOI)

  • 10.4244/EIJ-D-19-00208

PubMed ID

  • 31289019

Additional Document Info

volume

  • 15

issue

  • 17