Cross-correlated relaxation between H1′ chemical shift anisotropy and H1′ - H2′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration Academic Article uri icon

Overview

MeSH Major

  • Magnetic Resonance Spectroscopy
  • Ribonucleosides

abstract

  • Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H-1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only alpha-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1' doublet. Dependence of the magnitude and the orientation of the H1' CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.

publication date

  • January 12, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/jp055774m

PubMed ID

  • 16471486

Additional Document Info

start page

  • 5

end page

  • 8

volume

  • 110

number

  • 1