Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: A transthoracic Doppler and myocardial contrast echocardiography study Academic Article uri icon

Overview

MeSH Major

  • Aortic Valve Stenosis
  • Apoptosis
  • Coronary Circulation

abstract

  • Patients with severe aortic stenosis and LV hypertrophy have impaired myocardial perfusion, which is associated with enhanced cardiomyocyte apoptosis. Impaired myocardial perfusion and the ensuing oxygen demand-supply imbalance may, at least partially, be responsible for increased apoptosis and possible transition to heart failure, thus establishing a link between pressure overload, LV remodelling, and heart failure.

publication date

  • February 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1860772

Digital Object Identifier (DOI)

  • 10.1136/hrt.2005.062422

PubMed ID

  • 15908482

Additional Document Info

start page

  • 208

end page

  • 12

volume

  • 92

number

  • 2