Changing face of irritable bowel syndrome Editorial Article uri icon


MeSH Major

  • Irritable Bowel Syndrome


  • Recent years have witnessed tremendous progress in our understanding of irritable bowel syndrome (IBS). It is evident that this is a truly global disease associated with significant symptoms and impairments in personal and social functioning for afflicted individuals. Advances in our understanding of gut flora-mucosal interactions, the enteric nervous system and the brain-gut axis have led to substantial progress in the pathogenesis of symptoms in IBS and have provided some hints towards the basic etiology of this disorder, in some subpopulations, at the very least. We look forward to a time when therapy will be addressed to pathophysiology and perhaps, even to primary etiology. In the meantime, a model based on a primary role for intestinal inflammation serves to integrate the various strands, which contribute to the presentation of IBS.

publication date

  • January 7, 2006



  • Editorial



  • eng

PubMed Central ID

  • PMC4077493

PubMed ID

  • 16440408

Additional Document Info

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end page

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