Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients. Academic Article uri icon

Overview

abstract

  • We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

publication date

  • April 25, 2019

Research

keywords

  • Breast Neoplasms
  • Transcriptome

Identity

Scopus Document Identifier

  • 85064808285

Digital Object Identifier (DOI)

  • 10.1111/tbj.13256

PubMed ID

  • 31025467

Additional Document Info

volume

  • 25

issue

  • 4