Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study. Academic Article uri icon

Overview

abstract

  • Findings from in vivo brain proton magnetic resonance spectroscopy (1H MRS) and preclinical studies have suggested region- and medication status-dependent increases in glutamate (Glu) levels and deficiencies in glutathione (GSH) levels in schizophrenia. N-acetylcysteine (NAC), a GSH synthesis precursor, has demonstrated modest clinical benefit in schizophrenia. The objective of this study was to examine the effects of acute administration of NAC on GSH and Glu levels measured with 1H MRS in 19 patients with schizophrenia and 20 healthy control subjects. Levels of GSH were acquired in dorsal anterior cingulate cortex (dACC), and those of Glu in dACC and medial prefrontal cortex (mPFC), at baseline and 60 min following acute oral administration of 2400 mg of NAC. No differences in the levels of GSH or Glu were found at baseline or following NAC administration between patients with schizophrenia and control subjects in either of the targeted brain regions. Future studies measuring GSH levels in brain regions previously found to exhibit glutamatergic abnormalities or using genetic polymorphisms, while controlling for the age and medication status of the cohorts, are warranted to better identify groups of patients more likely to respond to NAC and its mode of action and mechanisms.

publication date

  • March 12, 2019

Research

keywords

  • Acetylcysteine
  • Free Radical Scavengers
  • Glutamic Acid
  • Glutathione
  • Gyrus Cinguli
  • Prefrontal Cortex
  • Schizophrenia

Identity

PubMed Central ID

  • PMC6515541

Scopus Document Identifier

  • 85062805497

Digital Object Identifier (DOI)

  • 10.1016/j.psychres.2019.03.018

PubMed ID

  • 30884334

Additional Document Info

volume

  • 275