Cancer Metabolism Drives a Stromal Regenerative Response. Review uri icon

Overview

abstract

  • The metabolic reprogramming associated with malignant transformation has led to a growing appreciation of the nutrients required to support anabolic cell growth. Less well studied is how cancer cells satisfy those demands in vivo, where they are dispersed within a complex microenvironment. Tumor-associated stromal components can support tumor growth by providing nutrients that supplement those provided by the local vasculature. These non-malignant stromal cells are phenotypically similar to those that accumulate during wound healing. Owing to their immediate proximity, stromal cells are inevitably affected by the metabolic activity of their cancerous neighbors. Until recently, a role for tumor cell metabolism in influencing the cell fate decisions of neighboring stromal cells has been underappreciated. Here, we propose that metabolites consumed and released by tumor cells act as paracrine factors that regulate the non-malignant cellular composition of a developing tumor by driving stromal cells toward a regenerative response that supports tumor growth.

publication date

  • February 14, 2019

Research

keywords

  • Carcinogenesis
  • Cell Transformation, Neoplastic
  • Stromal Cells
  • Tumor Microenvironment

Identity

PubMed Central ID

  • PMC6692899

Scopus Document Identifier

  • 85062110233

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2019.01.015

PubMed ID

  • 30773467

Additional Document Info

volume

  • 29

issue

  • 3