Pulmonary hypertension in chronic lung disease and hypoxia. Review uri icon

Overview

abstract

  • Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment. Who, when, if and how to screen for PH will be addressed in this article, as will the current state of knowledge with regard to the role of treatment with pulmonary vasoactive agents. Although such therapy cannot be endorsed given the current state of findings, future studies in this area are strongly encouraged.

publication date

  • January 24, 2019

Research

keywords

  • Hypertension, Pulmonary
  • Hypoxia
  • Lung Diseases, Interstitial
  • Pulmonary Disease, Chronic Obstructive

Identity

PubMed Central ID

  • PMC6351338

Scopus Document Identifier

  • 85060521466

Digital Object Identifier (DOI)

  • 10.1183/13993003.01914-2018

PubMed ID

  • 30545980

Additional Document Info

volume

  • 53

issue

  • 1