Association of albuminuria with all-cause and cardiovascular disease mortality in diabetes: The Strong Heart Study
Ventricular Function, Left
Objectives - To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods - A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results - Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% Cl 1.15-1.77 for all-cause, and HR=1.48, Cl 1.01-2.17 for CVD), and macroalbuminuria (HR=3.39, Cl 2.71-4.25 for all-cause, and HR=3.74, Cl 2.56-5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions - Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD mortality in American Indians with diabetes.