WNT Signaling in Cancer Immunosurveillance. Review uri icon

Overview

abstract

  • Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.

publication date

  • September 13, 2018

Research

keywords

  • Immunologic Surveillance
  • Immunotherapy
  • Neoplasms
  • Wnt Proteins
  • Wnt Signaling Pathway

Identity

PubMed Central ID

  • PMC7001864

Scopus Document Identifier

  • 85053106563

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2018.08.005

PubMed ID

  • 30220580

Additional Document Info

volume

  • 29

issue

  • 1