Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension. Academic Article uri icon

Overview

abstract

  • Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca2+-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lower pulmonary vascular resistance, and a trend towards better long-term survival compared to control animals.

publication date

  • August 21, 2018

Identity

PubMed Central ID

  • PMC6146327

Scopus Document Identifier

  • 85054859380

Digital Object Identifier (DOI)

  • 10.1177/2045894018799738

PubMed ID

  • 30129881

Additional Document Info

volume

  • 8

issue

  • 4