Kinetics of cancer: A method to test hypotheses of genetic causation Academic Article uri icon

Overview

MeSH Major

  • Age of Onset
  • Genotype
  • Mutation
  • Neoplasms

abstract

  • Many animal experiments compare qualitatively the onset curves for different genotypes. If such experiments were designed to analyze kinetics, the research could move to the next stage in which the mechanistic consequences of particular genetic pathways are related to the dynamics of carcinogenesis. The data we analyzed here were not collected to test mechanistic and quantitative hypotheses about kinetics. Even so, a simple reanalysis revealed significant insights about how DNA repair genotypes affect separately the age of onset and the acceleration of cancer. Our method of comparing genotypes provides good statistical tests even with small samples for each genotype.

publication date

  • December 21, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1352380

Digital Object Identifier (DOI)

  • 10.1186/1471-2407-5-163

PubMed ID

  • 16371164

Additional Document Info

start page

  • 163

volume

  • 5