HDL cholesterol and protective factors in atherosclerosis Review uri icon

Overview

MeSH Major

  • Arteriosclerosis
  • Cholesterol, HDL

abstract

  • A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholesterol transport, its effects on endothelial cells, and its antioxidant activity. Although some clinical trials suggest a benefit of raising HDL-C to reduce risk, further studies are needed, and HDL-C is still not considered a primary target of therapy in the National Cholesterol Education Program guidelines. However, HDL-C should be considered as part of the patient's overall profile of established risk factors in determining treatment strategies.

publication date

  • June 15, 2004

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 15198960

Additional Document Info

start page

  • III8

end page

  • 14

volume

  • 109

number

  • 23 SUPPL.