The utility of p16INK4a and Ki-67 staining on cell blocks prepared from residual thin-layer cervicovaginal material Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell
  • Cervical Intraepithelial Neoplasia
  • Cyclin-Dependent Kinase Inhibitor p16
  • Ki-67 Antigen
  • Papanicolaou Test
  • Uterine Cervical Neoplasms
  • Vaginal Smears

abstract

  • To the authors' knowledge, p16INK4a has not been analyzed previously in ThinPrep cell blocks, and the correlation between Ki-67 expression and cell block diagnoses also has not been reported previously. The current results indicate that cell blocks prepared from residual ThinPrep material represent an additional reliable diagnostic tool in the evaluation of cervical samples. Furthermore, immunohistochemical studies may be helpful in differentiating significant preneoplastic changes from other cervical lesions, such as atrophy.

publication date

  • June 25, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.20258

PubMed ID

  • 15211472

Additional Document Info

start page

  • 142

end page

  • 9

volume

  • 102

number

  • 3