Role of promoter hypermethylation in cisplatin treatment response of male germ cell tumors Academic Article uri icon

Overview

MeSH Major

  • Cisplatin
  • DNA Methylation
  • Germinoma
  • Promoter Regions, Genetic
  • Testicular Neoplasms

abstract

  • Our findings suggest that promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin. These results also implicate defects in epigenetic pathways that regulate gene transcription in cisplatin resistant GCT.

publication date

  • May 18, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC420487

Digital Object Identifier (DOI)

  • 10.1186/1476-4598-3-16

PubMed ID

  • 15149548

Additional Document Info

start page

  • 16

volume

  • 3