Tissue expression of transforming growth factor-β1 and its receptors: Correlation with pathologic features and biochemical progression in patients undergoing radical prostatectomy
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Our results showed that abnormal expression of TGF-beta1 and its receptors is common in prostate cancer. TGF-beta1 overexpression is moderately but significantly associated with a loss of expression of TGFbeta-RI and TGFbeta-RII. Loss of TGFbeta-RI expression is a prognostic marker in patients with prostate cancer.