Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation Academic Article uri icon

Overview

MeSH Major

  • Endothelium, Vascular
  • NADPH Oxidase
  • Smoke
  • Superoxides
  • Tobacco

abstract

  • These studies demonstrate that thiol-reactive stable compounds in CS can activate NADPH oxidase and increase endothelial O2* production, thereby reducing NO bioactivity and resulting in endothelial dysfunction. Clinically, these studies may contribute to the development of agents able to mitigate CS-mediated vascular toxicity.

publication date

  • June 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.ATV.0000127083.88549.58

PubMed ID

  • 15059808

Additional Document Info

start page

  • 1031

end page

  • 6

volume

  • 24

number

  • 6