Faithful Artificial Chromosome Propagation Using Spermatogonial Stem Cells. Academic Article uri icon

Overview

abstract

  • Artificial chromosomes are useful in making functional vectors for very large genes, studying chromosome physiology, and modeling chromosomal disorders. Shinohara et al. have succeeded for the first time in creating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superior chromosomal stability compared with embryonic stem cells (ESCs).

publication date

  • October 26, 2017

Research

keywords

  • Adult Stem Cells
  • Chromosome Disorders
  • Chromosomes, Artificial
  • Embryonic Stem Cells
  • Spermatogonia

Identity

PubMed Central ID

  • PMC5701830

Scopus Document Identifier

  • 85032347245

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2017.10.003

PubMed ID

  • 29107344

Additional Document Info

volume

  • 33

issue

  • 12