Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: Molecular analysis of the IDEAL/INTACT gefitinib trials Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Gene Amplification
  • Lung Neoplasms
  • Mutation
  • Quinazolines
  • Receptor, Epidermal Growth Factor

abstract

  • EGFR mutations and, to a lesser extent, amplification appear to identify distinct subsets of NSCLC with an increased response to gefitinib. The combination of gefitinib with chemotherapy does not improve survival in patients with these molecular markers.

publication date

  • December 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2005.02.7078

PubMed ID

  • 16204011

Additional Document Info

start page

  • 8081

end page

  • 92

volume

  • 23

number

  • 31