Behavioral outcome measures to improve experimental stroke research. Review uri icon

Overview

abstract

  • Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

publication date

  • July 29, 2017

Research

keywords

  • Disease Models, Animal
  • Stroke

Identity

Scopus Document Identifier

  • 85026867546

Digital Object Identifier (DOI)

  • 10.1016/j.bbr.2017.07.039

PubMed ID

  • 28760700

Additional Document Info

volume

  • 352