Distinct sets of genetic alterations in melanoma Academic Article uri icon

Overview

MeSH Major

  • DNA, Neoplasm
  • Genes, ras
  • Melanoma
  • Mutation
  • Proto-Oncogene Proteins B-raf
  • Skin Neoplasms
  • Ultraviolet Rays

abstract

  • The genetic alterations identified in melanomas at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.

publication date

  • November 17, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa050092

PubMed ID

  • 16291983

Additional Document Info

start page

  • 2135

end page

  • 47

volume

  • 353

number

  • 20