Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium trials 01-03 and 00-01 Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Gene Expression Regulation, Neoplastic
  • Glioma
  • Receptor, Epidermal Growth Factor

abstract

  • As erlotinib and gefitinib were generally ineffective at markedly inhibiting EGFR phosphorylation in these tumors, other assays may be needed to detect molecular effects. Additionally, the mechanism of erlotinib/gefitinib sensitivity likely differs between brain and lung tumors. Finally, novel genomic changes, including deletions of chromosomes 6, 21, and 22, represent new targets for further research.

publication date

  • November 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-05-0421

PubMed ID

  • 16278407

Additional Document Info

start page

  • 7841

end page

  • 50

volume

  • 11

number

  • 21