Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Academic Article uri icon

Overview

MeSH

  • Adult
  • Brain Mapping
  • Female
  • Follicular Phase
  • Humans
  • Luteal Phase
  • Magnetic Resonance Imaging

MeSH Major

  • Cerebral Cortex
  • Emotions
  • Menstrual Cycle

abstract

  • The orbitofrontal cortex (OFC) has been implicated in the representation of emotional stimuli, assignment of emotional valence/salience to stimuli, stimulus-reinforcement association learning, motivation, and socio-emotional control. Using functional magnetic resonance imaging in female subjects without premenstrual mood symptoms, we found that OFC activity to emotional linguistic stimuli varies depending on the menstrual cycle phase. Specifically, anterior-medial OFC activity for negative vs. neutral stimuli was increased premenstrually and decreased postmenstrually. The inverse pattern was seen in the lateral OFC. These findings suggest that specific subregional OFC activity to emotional stimuli is modulated across the menstrual cycle. The data also demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation.

publication date

  • November 1, 2005

has subject area

  • Adult
  • Brain Mapping
  • Cerebral Cortex
  • Emotions
  • Female
  • Follicular Phase
  • Humans
  • Luteal Phase
  • Magnetic Resonance Imaging
  • Menstrual Cycle

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1276043

Digital Object Identifier (DOI)

  • 10.1073/pnas.0502818102

PubMed ID

  • 16247013

Additional Document Info

start page

  • 16060

end page

  • 16065

volume

  • 102

number

  • 44