A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials. Academic Article uri icon

Overview

abstract

  • Over the past decade, the rate of drug attrition due to clinical trial failures has risen substantially. Unfortunately it is difficult to identify compounds that have unfavorable toxicity properties before conducting clinical trials. Inspired by the effective use of sabermetrics in predicting successful baseball players, we sought to use a similar "moneyball" approach that analyzes overlooked features to predict clinical toxicity. We introduce a new data-driven approach (PrOCTOR) that directly predicts the likelihood of toxicity in clinical trials. PrOCTOR integrates the properties of a compound's targets and its structure to provide a new measure, the PrOCTOR score. Drug target network connectivity and expression levels, along with molecular weight, were identified as important indicators of adverse clinical events. Our method provides a data-driven, broadly applicable strategy to identify drugs likely to possess manageable toxicity in clinical trials and will help drive the design of therapeutic agents with less toxicity.

publication date

  • September 15, 2016

Research

keywords

  • Computational Biology
  • Drug Discovery
  • Drug-Related Side Effects and Adverse Reactions

Identity

PubMed Central ID

  • PMC5074862

Scopus Document Identifier

  • 84993985653

Digital Object Identifier (DOI)

  • 10.1016/j.chembiol.2016.07.023

PubMed ID

  • 27642066

Additional Document Info

volume

  • 23

issue

  • 10