Discovery of a biologically active thiostrepton fragment Academic Article uri icon

Overview

MeSH Major

  • Enterococcus faecalis
  • Escherichia coli
  • Plasmodium falciparum
  • Staphylococcus
  • Thiostrepton

abstract

  • Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.

publication date

  • November 2, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/ja0552803

PubMed ID

  • 16248640

Additional Document Info

start page

  • 15042

end page

  • 4

volume

  • 127

number

  • 43