Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus. Academic Article uri icon

Overview

abstract

  • Six sesquiterpenoids 1-6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A-D 3-6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).

publication date

  • December 25, 2014

Research

keywords

  • Aspergillus
  • Sesquiterpenes

Identity

PubMed Central ID

  • PMC6272214

Scopus Document Identifier

  • 84921648331

Digital Object Identifier (DOI)

  • 10.3390/molecules20010325

PubMed ID

  • 25547729

Additional Document Info

volume

  • 20

issue

  • 1