The role of ventral frontostriatal circuitry in reward-based learning in humans Academic Article uri icon


MeSH Major

  • Corpus Striatum
  • Frontal Lobe
  • Learning
  • Nerve Net
  • Reward


  • This study examined changes in behavior and neural activity with reward learning. Using an event-related functional magnetic resonance imaging paradigm, we show that the nucleus accumbens, thalamus, and orbital frontal cortex are each sensitive to reward magnitude, with the accumbens showing the greatest discrimination between reward values. Mean reaction times were significantly faster to cues predicting the greatest reward and slower to cues predicting the smallest reward. This behavioral change over the course of the experiment was paralleled by a shift in peak in accumbens activity from anticipation of the reward (immediately after the response), to the cue predicting the reward. The orbitofrontal and thalamic regions peaked in anticipation of the reward throughout the experiment. Our findings suggest discrete functions of regions within basal ganglia thalamocortical circuitry in adjusting behavior to maximize reward.

publication date

  • September 21, 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2431-05.2005

PubMed ID

  • 16177032

Additional Document Info

start page

  • 8650

end page

  • 6


  • 25


  • 38