Toward fully synthetic glycoproteins by ultimately convergent routes: A solution to a long-standing problem Academic Article uri icon

Overview

MeSH Major

  • Glycoproteins

abstract

  • A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a convergent technique for generating masked, complex glycopeptide-containing C-terminal acyl donors. Activation of the latent donor in situ and use directly in segment coupling with a second peptide bearing a complex carbohydrate produces a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal amino acid residue of the acyl donor during fully convergent segment coupling and is therefore a powerful tool for the synthesis of glycoproteins.

publication date

  • June 2, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/ja0491836

PubMed ID

  • 15161285

Additional Document Info

start page

  • 6576

end page

  • 8

volume

  • 126

number

  • 21