Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder. Academic Article uri icon

Overview

abstract

  • Rapid eye movement sleep behaviour disorder has been evaluated using Parkinson's disease-related metabolic network. It is unknown whether this disorder is itself associated with a unique metabolic network. 18F-fluorodeoxyglucose positron emission tomography was performed in 21 patients (age 65.0±5.6 years) with idiopathic rapid eye movement sleep behaviour disorder and 21 age/gender-matched healthy control subjects (age 62.5±7.5 years) to identify a disease-related pattern and examine its evolution in 21 hemi-parkinsonian patients (age 62.6±5.0 years) and 16 moderate parkinsonian patients (age 56.9±12.2 years). We identified a rapid eye movement sleep behaviour disorder-related metabolic network characterized by increased activity in pons, thalamus, medial frontal and sensorimotor areas, hippocampus, supramarginal and inferior temporal gyri, and posterior cerebellum, with decreased activity in occipital and superior temporal regions. Compared to the healthy control subjects, network expressions were elevated (P<0.0001) in the patients with this disorder and in the parkinsonian cohorts but decreased with disease progression. Parkinson's disease-related network activity was also elevated (P<0.0001) in the patients with rapid eye movement sleep behaviour disorder but lower than in the hemi-parkinsonian cohort. Abnormal metabolic networks may provide markers of idiopathic rapid eye movement sleep behaviour disorder to identify those at higher risk to develop neurodegenerative parkinsonism.

publication date

  • October 22, 2014

Research

keywords

  • Eye Movements
  • Metabolic Networks and Pathways
  • Nerve Net
  • Parkinson Disease
  • REM Sleep Behavior Disorder

Identity

PubMed Central ID

  • PMC4240297

Scopus Document Identifier

  • 84922371521

Digital Object Identifier (DOI)

  • 10.1093/brain/awu290

PubMed ID

  • 25338949

Additional Document Info

volume

  • 137

issue

  • Pt 12