Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium Academic Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Fetal Tissue Transplantation
  • Graft Rejection
  • Heart Neoplasms
  • Myocardial Ischemia
  • Myocardium
  • Pluripotent Stem Cells
  • Postoperative Complications
  • Stem Cell Transplantation
  • Teratoma

abstract

  • In vivo differentiated ESCs elicit an accelerated immune response as compared with undifferentiated ESCs. These data imply that clinical transplantation of allogeneic ESCs or ESC derivatives for treatment of cardiac failure might require immunosuppressive therapy.

publication date

  • August 30, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.104.525824

PubMed ID

  • 16159810

Additional Document Info

start page

  • I166

end page

  • 72

volume

  • 112

number

  • 9 SUPPL.