The IL-6 feed-forward loop: a driver of tumorigenesis. Review uri icon

Overview

abstract

  • IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed.

publication date

  • March 6, 2014

Research

keywords

  • Cell Transformation, Neoplastic
  • Interleukin-6
  • Neoplasms
  • Signal Transduction

Identity

Scopus Document Identifier

  • 84896491618

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2014.01.007

PubMed ID

  • 24613573

Additional Document Info

volume

  • 26

issue

  • 1