Association of preoperative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion molecule-1 with lymph node status and biochemical progression after radical prostatectomy Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Neovascularization, Pathologic
  • Prostatectomy
  • Prostatic Neoplasms
  • Vascular Cell Adhesion Molecule-1
  • Vascular Endothelial Growth Factor A

abstract

  • Plasma levels of VEGF increased incrementally from healthy controls to patients with clinically localized disease to patients with lymph node and skeletal metastases. Higher preoperative VEGF was independently associated with metastases to lymph nodes and biochemical progression after surgery in both pre- and postoperative models. Plasma sVCAM-1 was elevated in men with bone metastases and was associated with biochemical progression in a preoperative model.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2004.09.142

PubMed ID

  • 15117988

Additional Document Info

start page

  • 1655

end page

  • 63

volume

  • 22

number

  • 9