Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP1A1
In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10. © Oxford University Press 2004; all rights reserved.
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