Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract Academic Article uri icon

Overview

MeSH Major

  • Aryl Hydrocarbon Hydroxylases
  • Benzo(a)pyrene
  • Cytochrome P-450 CYP1A1
  • Glucuronides
  • Isoenzymes
  • Leukoplakia, Oral
  • Prostaglandin-Endoperoxide Synthases

abstract

  • In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10. © Oxford University Press 2004; all rights reserved.

publication date

  • May 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/carcin/bgh078

PubMed ID

  • 14729581

Additional Document Info

start page

  • 793

end page

  • 9

volume

  • 25

number

  • 5