Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Carcinoma, Non-Small-Cell Lung
  • Deoxycytidine
  • Hydroxamic Acids
  • Lung Neoplasms

abstract

  • Combined SAHA and gemcitabine sensitized NSCLC cells to apoptosis. Potential "proapoptotic" mechanisms for this finding include gemcitabine inhibition of SAHA-induced NF-kappaB activation and chromatin remodeling mediated by the inhibition of histone deacetylases.

publication date

  • August 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.surg.2005.06.016

PubMed ID

  • 16153448

Additional Document Info

start page

  • 360

end page

  • 7

volume

  • 138

number

  • 2