Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Endometrial Neoplasms
  • Gene Frequency
  • Neoplasm Proteins
  • Nuclear Proteins

abstract

  • The MLH1 D132H risk variant has significantly lower allele frequency in American compared with Israeli cancer patients and, alone, is unlikely to explain significant amounts of American sporadic colorectal cancer or uterine cancer susceptibility. Genetic testing for the MLH1 D132H allele exclusively is therefore unlikely to be cost effective for genetic risk assessment in American population-based and clinic-based colorectal cancer and endometrial cancer patients.

publication date

  • September 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s10350-005-0123-8

PubMed ID

  • 15991064

Additional Document Info

start page

  • 1723

end page

  • 7

volume

  • 48

number

  • 9