The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study Academic Article uri icon

Overview

MeSH Major

  • Adrenergic beta-Antagonists
  • Angiotensin II Type 1 Receptor Blockers
  • Aspirin
  • Atenolol
  • Hypertension
  • Hypertrophy, Left Ventricular
  • Losartan

abstract

  • There was a statistical interaction between treatment and aspirin in the LIFE study, with significantly greater reductions for the CEP and MI with losartan in patients using aspirin than in patients not using aspirin at baseline. Further studies are needed to clarify whether this represents a pharmacologic interaction or a selection by aspirin use of patients more likely to respond to losartan treatment.

publication date

  • September 6, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2005.05.060

PubMed ID

  • 16139123

Additional Document Info

start page

  • 770

end page

  • 5

volume

  • 46

number

  • 5