Immunology: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function Academic Article uri icon


MeSH Major

  • CD4-Positive T-Lymphocytes
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Signal Transduction
  • T-Lymphocyte Subsets


  • CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.

publication date

  • August 26, 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1113401

PubMed ID

  • 16123302

Additional Document Info

start page

  • 1380

end page

  • 4


  • 309


  • 5739