Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Iodine Radioisotopes
  • Membrane Glycoproteins
  • Radioimmunotherapy
  • Radiopharmaceuticals
  • Streptavidin

abstract

  • SS1scFvSA localized in the mesothelin-expressing tumor, resulting in a high accumulation of radiolabeled DOTA-biotin. The specific activity of DOTA-biotin had a significant effect on its tumor uptake. Therapeutic tumor doses were obtained without dose-limiting toxicity.

publication date

  • December 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 16000290

Additional Document Info

start page

  • 1201

end page

  • 9

volume

  • 46

number

  • 7