Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin.
Dose-Response Relationship, Drug
In Vitro Techniques
Mice, Inbred C57BL
Gene Transfer Techniques
The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.