Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin. Academic Article uri icon

Overview

MeSH

  • Animals
  • Cell Membrane
  • Chemokines
  • DNA, Complementary
  • Dose-Response Relationship, Drug
  • Gene Deletion
  • Genetic Vectors
  • Hair
  • Hedgehog Proteins
  • In Vitro Techniques
  • Keratinocytes
  • Mice
  • Mice, Inbred C57BL

MeSH Major

  • Adenoviridae
  • Cholesterol
  • Gene Transfer Techniques
  • Skin
  • Trans-Activators

abstract

  • The role of Sonic hedgehog (Shh) as a morphogen in diverse developmental settings depends on covalent addition of cholesterol. In this study, expression of Shh lacking cholesterol stimulated hair growth with greater efficacy than native Shh, suggesting that Shh acts as a chemokine rather than a morphogen in this postnatal role. Thus, a structural modification that renders a morphogen ineffective in developmental models may have distinct advantages for postnatal applications.

publication date

  • September 2005

has subject area

  • Adenoviridae
  • Animals
  • Cell Membrane
  • Chemokines
  • Cholesterol
  • DNA, Complementary
  • Dose-Response Relationship, Drug
  • Gene Deletion
  • Gene Transfer Techniques
  • Genetic Vectors
  • Hair
  • Hedgehog Proteins
  • In Vitro Techniques
  • Keratinocytes
  • Mice
  • Mice, Inbred C57BL
  • Skin
  • Trans-Activators

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ymthe.2005.01.009

PubMed ID

  • 15987672

Additional Document Info

start page

  • 575

end page

  • 578

volume

  • 12

number

  • 3