Introduction to the 2002 Annual Conference Manuscripts: Can aging of the brain be reversed? From basic science to the clinical arena Conference Paper uri icon


MeSH Major

  • Antidepressive Agents, Second-Generation
  • Citalopram
  • Depressive Disorder, Major
  • Placebo Effect


  • Pasteurella haemolytica organisms grown in vivo were examined for their susceptibility to ovine immune mechanisms in vitro. Compared with in vitro grown organisms they were less susceptible to opsonophagocytosis and, in contrast, susceptible to complement-dependent killing in the absence of exogenous antibody. These differences were not associated with phenotypic changes in the surface of the bacterial cell. However, overproduction and de novo synthesis of proteins was observed in in vivo grown organisms. Also, bound host-immunoglobulin was observed on in vivo grown organisms and a role for this in modifying the interaction with immune mechanisms is discussed.

publication date

  • January 2003



  • Conference Paper


Digital Object Identifier (DOI)

  • 10.1016/S1566-2772(03)00002-1

Additional Document Info

start page

  • 269

end page

  • 78


  • 2


  • 5-6