Neuroimaging studies of fronto-limbic dysfunction in geriatric depression Conference Paper uri icon

Overview

MeSH Major

  • Antidepressive Agents, Second-Generation
  • Citalopram
  • Depressive Disorder, Major
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging

abstract

  • Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 week's antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant (p less than 0.01) decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

publication date

  • January 2003

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1016/S1566-2772(03)00009-4

Additional Document Info

start page

  • 324

end page

  • 7

volume

  • 2

number

  • 5-6