Engaging the vascular component of the tumor response Article uri icon

Overview

MeSH Major

  • DNA-Binding Proteins
  • Endothelium, Vascular
  • Neoplasms
  • Neovascularization, Pathologic
  • Nuclear Proteins
  • Transcription Factors

abstract

  • Recent research has shed new light on the critical role of tissue microvasculature in regulating the tumor response to radiation and drugs. In this issue of Cancer Cell, Moeller et al.(2005) demonstrate that HIF-1 activation during the course of fractionated radiotherapy initiates pleiotropic adaptive responses in both tumor cells and the microvascular network, radiosensitizing tumor cells but concomitantly conferring tumor radioresistance due to protection of the microvascular endothelium. HIF-1 thus serves as a legitimate target for differential modulation of tissue response to radiation.

publication date

  • August 2005

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2005.07.014

Additional Document Info

start page

  • 89

end page

  • 91

volume

  • 8

number

  • 2