Targeting malaria parasite proteins to the erythrocyte. Review uri icon

Overview

MeSH

  • Amino Acid Sequence
  • Animals
  • Genes, Protozoan
  • Host-Parasite Interactions
  • Humans
  • Sequence Alignment

MeSH Major

  • Erythrocytes
  • Malaria, Falciparum
  • Plasmodium falciparum
  • Protozoan Proteins
  • Vacuoles

abstract

  • The intraerythrocytic stages of the protozoan parasite Plasmodium falciparum reside within a parasitophorous vacuole (PV) and set up unique "extraparasite, intraerythrocyte" protein-trafficking pathways that target parasite-encoded proteins to the erythrocyte cytoplasm and cell surface. Two recent articles report the identification of trafficking motifs that regulate the transport of parasite-encoded proteins across the PV. These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane.

publication date

  • September 2005

has subject area

  • Amino Acid Sequence
  • Animals
  • Erythrocytes
  • Genes, Protozoan
  • Host-Parasite Interactions
  • Humans
  • Malaria, Falciparum
  • Plasmodium falciparum
  • Protozoan Proteins
  • Sequence Alignment
  • Vacuoles

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.pt.2005.07.006

PubMed ID

  • 16046185

Additional Document Info

start page

  • 399

end page

  • 402

volume

  • 21

number

  • 9