Regulation of Phagosome Maturation by Signals from Toll-Like Receptors Academic Article uri icon

Overview

MeSH Major

  • Bacteria
  • Macrophages
  • Membrane Glycoproteins
  • Phagocytosis
  • Phagosomes
  • Receptors, Cell Surface
  • Signal Transduction

abstract

  • In higher metazoans, phagocytosis is essential in host defense against microbial pathogens and in clearance of apoptotic cells. Both microbial and apoptotic cells are delivered on a common route from phagosomes to lysosomes for degradation. Here, we found that activation of the Toll-like receptor (TLR) signaling pathway by bacteria, but not apoptotic cells, regulated phagocytosis at multiple steps including internalization and phagosome maturation. Phagocytosis of bacteria was impaired in the absence of TLR signaling. Two modes of phagosome maturation were observed, constitutive and inducible; their differential engagement depended on the ability of the cargo to trigger TLR signaling.

publication date

  • May 14, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1096158

PubMed ID

  • 15143282

Additional Document Info

start page

  • 1014

end page

  • 8

volume

  • 304

number

  • 5673