Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Phytogenic
  • Camptothecin
  • Glucuronosyltransferase
  • Neutropenia
  • Topoisomerase I Inhibitors

abstract

  • UGT1A1 genotype and total bilirubin levels are strongly associated with severe neutropenia, and could be used to identify cancer patients predisposed to the severe toxicity of irinotecan. The hypothesis that the -3156G>A variant is a better predictor of UGT1A1 status than the previously reported TA indel requires further testing.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2004.07.173

PubMed ID

  • 15007088

Additional Document Info

start page

  • 1382

end page

  • 8

volume

  • 22

number

  • 8