The Development of Interval Breast Malignancies in Patients with BRCA Mutations Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Genes, BRCA1
  • Genes, BRCA2
  • Mutation

abstract

  • Nearly half of all BRCA-positive women who chose to undergo close surveillance in the current study developed malignant disease less than a year after exhibiting normal findings on screening mammography. Half of these interval malignancies were positive for lymph node involvement. These results suggest that strong consideration should be given to screening BRCA-positive women at more frequent intervals and to using additional imaging techniques, such as breast ultrasonography and/or breast magnetic resonance imaging, as a part of this screening.

publication date

  • May 15, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.20221

PubMed ID

  • 15139048

Additional Document Info

start page

  • 2079

end page

  • 83

volume

  • 100

number

  • 10