Fear-related activity in subgenual anterior cingulate differs between men and women Academic Article Article uri icon


MeSH Major

  • Alzheimer Disease
  • Leuprolide


  • Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

publication date

  • August 2005



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1097/00001756-200508010-00020

PubMed ID

  • 16012355

Additional Document Info

start page

  • 1233

end page

  • 6


  • 16


  • 11